MULTI-SPECIES CRO

Multi-Species CRO Contract Research

The world's first genomics CRO platform covering Horse, Donkey & Alpaca
Powered by cross-species comparative genomics for breeding, biopharma, and translational research

Cross-Species Comparative Genomics

The world's exclusive VicPac4 chromosome-level integration, building a four-way Human-Horse-Donkey-Alpaca comparative genomics framework — the intelligent cross-species genomic layer for translational medicine and breeding decisions

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Core Moat: 56/63 core genes achieve complete Human-Horse-Donkey-Alpaca four-way mapping (88.9%), 145 horse-donkey chromosome pairs, 30,872 full-length orthologous genes — the world's only comparative genomics platform covering four species at chromosome-level assemblies.
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Horse Equus caballus

EquCab3.0
Genome Size: 2.43 Gb
Protein-coding Genes: ~20,386
Variant Sites: 40.15M+
Breeds Covered: 400+
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Human Homo sapiens

GRCh38
Genome Size: 3.09 Gb
Protein-coding Genes: ~20,000
Human-Horse Verified: 19,388
1:1 Orthologs: 15,697
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Donkey Equus asinus

ASM1607732v2
Genome Size: 2.43 Gb
Protein-coding Genes: ~18,728
Horse-Donkey Orthologs: 19,522
1:1 Orthologs: 17,641
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Alpaca Vicugna pacos

VicPac4
Genome Size: 2.57 Gb
Protein-coding Genes: 21,233
Horse-Alpaca Orthologs: 11,350
1:1 Orthologs: 9,841

Four-Way Mapping Key Metrics

56/63
Core Genes Four-Way
Human-Horse-Donkey-Alpaca 88.9% coverage
19,522
Horse-Donkey Orthologs
17,641 are 1:1 orthologs
11,350
Horse-Alpaca Orthologs
9,841 are 1:1 orthologs
145 Pairs
Chromosome Mapping
Horse-Donkey chromosome-level correspondence

Equine CRO Services

Leveraging the world's most comprehensive equine variant database (40.15M+ positions, 400+ breeds) and our proprietary NCDS v3.4 model, delivering end-to-end contract research from sample analysis to report delivery

🛡️ Hereditary Disease Screening

Batch hereditary disease testing for breeding operations. Covers 8+ diseases including HYPP, PSSM, and MH with standardized Clear / Carrier / At-Risk reporting.

🏇 Athletic Gene Genotyping

Precision genotyping of MSTN, DMRT3, and other performance-related genes with NCDS model-powered athletic aptitude assessment and training recommendations.

🔬 Breed ID & Kinship Analysis

STR/SNP genotyping based on 40.15M+ variant positions for parentage verification, breed purity analysis, and pedigree tracing. Now extended to multi-species identification for horse, donkey, and mule.

📊 WGS Data Analysis

Professional interpretation and reporting of whole-genome sequencing data. Full pipeline including variant calling, functional annotation, causal inference, and phenotype prediction.

🧬 Causal Variant Functional Research

Variant functional validation services for research collaborations. Leveraging the Tier A/B/C stratified database of 49,697 causal variant positions.

📋 Custom Data & Assay Design

Customized allele frequency data for specific breeds/populations. Custom PCR/SNP assay design tailored to client requirements.

Alpaca CRO Services

The CRO behind CROs — the genomic data intelligence layer. Based on VicPac4 chromosome-level assembly (21,233 protein-coding genes) and 7,208 human-alpaca homologous mappings, providing professional genomics services for alpaca breeding, nanobody development, and translational medicine

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Alpaca CRO Database: 13 tables, 3 views, 41,200 gene coordinates, 49 cataloged variants, 46 PGS effect sites, 19 target gene recommendations. The world's first systematic alpaca genomics CRO platform.

Core Product Suite

AlpacaGene™
Donor Screening Platform

🧬 Immune Response Genes + Yield Prediction

  • Intelligent donor screening based on immune response gene profiles
  • Nanobody yield prediction models
  • VHH sequence library management & affinity analysis
  • Donor population optimization & genetic diversity assessment
AVS-Alpaca™
Genetic Scoring System

📊 Eight-Dimensional Scoring System

  • Breeding value, fiber quality, coat color genetics
  • Health index, reproductive performance
  • Athletic ability, adaptability assessment
  • Nanobody potential composite scoring
DiseaseModel™
Model Matching Platform

🎯 Human-Alpaca Homolog Mapping + Phenotype Library

  • 7,208 human-alpaca homologous gene mappings
  • Targeted disease model intelligent matching
  • Nanobody drug target screening
  • Cross-species phenotype comparative analysis

Nanobody Platform Capabilities

🔬 VHH Sequence Platform

Alpaca natural nanobodies (VHH) are the smallest known functional antibody fragments, offering high affinity, stability, and tissue penetration.

  • VHH sequence library construction & management
  • Affinity maturation & optimization
  • Humanization engineering support
  • Multi-specific antibody design

💊 Application Areas

Alpaca nanobodies show tremendous potential in oncology, autoimmune diseases, infectious diseases, and diagnostic reagents.

  • Tumor targeted therapy (CD40, CD176/CDH17)
  • Inflammation & immune regulation (P2RX7)
  • Gene therapy evaluation models
  • In vitro diagnostics & biosensors

High-Value Target Genes Three Tiers

19 target genes organized in three tiers, covering the full pipeline from breeding commercialization to nanobody development and R&D evaluation

T1 Breeding Commercialization · 7 Market-Ready Genes

Core testing genes directly serving the alpaca breeding market, covering coat color, fiber quality, and health traits

MC1R
Coat color determination — base color control
KIT
Classic gray lethal gene — white phenotype association
KITLG
Pigment intensity GWAS — color depth regulation
ASIP
Coat color variation — Agouti signaling protein
TYRP1
Coat color auxiliary marker — tyrosinase-related protein
KRTAP / KRT
Fiber quality core — keratin & associated proteins
RYR1
Malignant hyperthermia — stress sensitivity marker

T2 Nanobody + CRO · 6 Target Genes

Core targets for nanobody drug development and CRO evaluation services

MSTN
Muscle development / gene therapy evaluation model
DMRT3
Gait control / motor neuron regulation
P2RX7
Inflammation marker / immune regulation target
CD40
Nanobody patent target — immune modulation
CD176 / CDH17
Tumor nanobody target
IGF1
Growth axis core — development & metabolic regulation

T3 R&D Reserve · 6 Genes

R&D reserve genes for long-term research collaboration and frontier exploration

Reserve Genes 1-6
Covering immune regulation, metabolic pathways, developmental biology and other R&D reserve targets, dynamically updated with research progress

Product Capability Upgrade

Cross-species genomics driving full product line upgrade — from single equine services to multi-species platform capabilities

Product ModuleBeforeAfter
JumpHealth™Horse onlyHorse + Donkey + Alpaca
Breed IdentificationHorse breeds onlyHorse / Donkey / Mule + Alpaca
Translational MedicineHuman-Horse mappingHuman-Horse-Donkey-Alpaca four-way
CRO Model RecommendationHorse + AlpacaHorse + Donkey + Alpaca three species

Service Models

Flexible service delivery models to meet diverse client requirements

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Sample Submission

Client ships biological samples (hair/buccal swab/blood) → GenoMatrix laboratory analysis → Report delivery

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Data Analysis

Client provides raw sequencing data (FASTQ/BAM/VCF) → GenoMatrix bioinformatics analysis → Report and data file delivery

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Custom Development

Tailored assay design, data products, or analysis workflows for specific client needs. Joint research grants and co-publication support available.

3
Species Covered
40.15M+
Equine Variants
21,233
Alpaca Gene Coordinates
7,208
Human-Alpaca Mappings
19
Alpaca Target Genes
90%
Core Gene Validation
📧 Inquire About Multi-Species CRO Services